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Amoxicillin + Sulbactam

Brand Name, Dosage Format and Strength
Ultramox  500 mg/500 mg Tablet


Amoxicillin + Sulbactam (Ultramox) 500 mg Suspension:

Usual pediatric dose: 20 to 40 mg/kg BW/day (based on amoxicillin) depending on the severity of infection; to be given in three divided doses (every 8 hrs).

Age Group
Dose Every 8 hrs
Children younger than 2 yrs
2.5 mL (1/2 tsp)
2 to 6 yrs
5 mL (1 tsp)
6 to 12 yrs
7.5 mL (1 1/2 tsp)
Children over 12 yrs old and Adults
10 to 20 mL (2 to 4 tsp)
Or, as prescribed by a physician.

Usual treatment duration:
7 to 14 days depending on the type and severity of infection

Directions for Reconstitution:
Tap bottle until all powder flows freely. Add 40 mL distilled water or up to the water mark level and shake vigorously until the contents are evenly suspended. Once reconstituted, the suspension must be stored in a refrigerator and used within 7 to 10 days. Keep container tightly closed. Shake well before use.

Amoxicillin + Sulbactam (Ultramox) 1000 mg Tablet:
Adults and Children over 12 yrs old: Orally, 1 tab every 8 hrs, or, as prescribed by a physician.
Usual treatment duration: 7 to 14 days depending on the type and severity of infection

Amoxicillin + Sulbactam (Ultramox) 750 mg and 1500 mg Vials:
Amoxicillin + sulbactam may be administered by deep IM injection, direct IV injection or IV infusion.

Pediatric Dose (Children 2 to 12 yrs old):
Usual dose is 60 to 75 mg/kg/day amoxicillin + sulbactam (40 to 50 mg/kg/day amoxicillin + 20 to 25 mg/kg/day sulbactam) given in two or three divided doses (every 8 or 12 hrs).
For severe infections, dosage may be increased up to 150 mg/kg/day amoxicillin + sulbactam (100 mg/kg/day amoxicillin + 50 mg/kg/day sulbactam).
Age Group
Dose of Amoxicillin + Sulbactam
Children 2 to 6 yrs
375 mg every 6 to 8 hrs
6 to 12 yrs
750 mg every 6 to 8 hrs
Adults and Children 12 yrs and older
1500 mg every 8 hrs
Or, as prescribed by a physician.

Usual treatment duration:
7 to 14 days depending on the type and severity of infection
The parenteral administration of this antibiotic is usually indicated for moderate to severe infections or when oral administration is not feasible. A shift to its oral format can be done once possible as determined by the physician.

irections for Reconstitution

IM or Direct IV injection
: Dissolve in 5 mL Sterile Water for Injection. Administer within 15 mins after preparation. Any unused portion of the solution must be discarded after the indicated time period.

To lower the incidence of local adverse effects during IM injection, it is recommended that these rules be closely followed:
· Clean injection site aseptically
· Keep the asepsis during manipulation
· Inject as deep as possible
· Inject slowly
· Make a soft massage to help drug absorption

For direct IV injection, administer as slowly as possible to prevent local adverse effects.
IV Infusion: Amoxicillin + sulbactam 750 mg or 1500 mg vial may also be administered by IV infusion using the diluents, maximum concentration of amoxicillin + sulbactam and the use period indicated in the following table:
Maximum concentration of Amoxicillin + sulbactam (mg/mL)
Use Periods
0.9% Sodium Chloride for Injection
5 hrs
12 hrs
Lactated Ringer’s Injection
5 hrs
6 hrs
Dextrose 5% Injection
2 hrs
4 hrs
Minimum volume of diluent for IV infusion: 25 mL for the 750 mg Vial
                                                                    50 mL for the 1500 mg Vial
Recommended duration of IV infusion: 30 to 40 mins

Amoxicillin + Sulbactam should not be mixed with aminoglycosides, blood derivatives and protein solutions because the drug is incompatible with these.

Reconstituted solutions must be discarded after the indicated use periods.

Last Update: Jul 21, 2011

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