IMPORTANT NOTE. We strongly recommend that you consult your doctor for proper advice before using any medications, including vitamins, supplements, herbals and products for the skin.
Brand Name, Dosage Format and Strength
Siverol 50mg/mL Solution for Injection
Therapeutic Category
Central Nervous System
Class
Opioid, Non-Opioids, NSAID, Anticonvulsant, Antiepileptic, Antidepressant, SSRI, Antipsychotic, Anti-Vertigo, CNS Stimulant, Neuroprotective Agent, Sedative, Hypnotic
DOSAGE AND ADMINISTRATION
Like any other analgesic drug, the dosing of tramadol should be adjusted according to the severity of pain and patient’s clinical response.
The lowest effective analgesic dose should be given.
Strict aseptic technique should be observed when drawing up the contents of tramadol ampule. If injection ampules become contaminated, they have the potential to become a source of infection to patients
Adults and children over 12 yrs old:
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DOSAGE FORM |
PAIN SEVERITY |
RECOMMENDED DOSE |
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FOR ORAL ADMINISTRATION:
Tramadol 50 mg Cap
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Moderate Pain |
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Moderate to Severe Pain |
(1 to 2 caps) as needed, every 4 to 6 hrs.
400 mg/day |
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FOR PARENTERAL ADMINISTRATION: IV or IM injection
Tramadol 50 mg/1 mL Solution for Injection or Tramadol 100 mg/2 mL Solution for Injection |
Postoperative pain |
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Less severe pain |
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IV injection should be given slowly over 2 to 3 mins. |
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Or, as prescribed by a physician |
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SPECIAL POPULATION:
Patients with Renal Impairment/Renal Dialysis
- Impaired renal function results in a decreased rate and extent of excretion of tramadol and M1. The usual initial adult doses should be employed, but the dosage interval should be adjusted.
- Creatinine clearance <30 mL/min: Dose interval should be increased to 12 hrs.
- Creatinine clearance <10 mL/min (severe renal impairment): Tramadol HCl is not recommended.
- Dialysis patients can receive their regular dose on the day of dialysis since only 7% of an administered dose is removed by hemodialysis.
- Tramadol is removed very slowly by hemodialysis or hemofiltration and therefore postdialysis dosing to maintain analgesia is usually unnecessary.
Patients with Hepatic Impairment
- An initial dose of 50 mg is given. Depending on the severity of the impairment and individual clinical response, the recommended dosage interval of 4 to 6 hrs may need to be extended, and/or the dose level titrated as required.
- Severe hepatic impairment: Elimination of tramadol may be prolonged in severe hepatic impairment including liver cirrhosis. Although the usual initial adult doses can be used, dosing should be at 12 hourly intervals.
Elderly patients
- Changes in renal and/or hepatic function in the elderly may require dose adjustment. Daily doses of 300 mg are not recommended in patients over 75 yrs.