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Immunosin
Inosiplex
Brand Name, Dosage Format and Strength
Immunosin 500 mg Tablet
Therapeutic Category
Anti-infectives (Systemic)
Class
Aminoglycoside, Cephalosporin, Chloramphenicol, Lincosamide, Macrolide, Penicillin, Penicillin + Beta lactamase Inhibitor , Penicillinase-resistant isoxazolylpenicillin, Penicillin; Beta-lactam + Beta-lactamase Inhibitor, Quinolone, Sulfonamide + Folate Inhibitor, Tetracycline, Triazole Antibiotic, Immunostimulant, Neuraminidase Inhibitor
CLINICAL PHARMACOLOGY
Pharmacodynamics
Inosiplex is used in the treatment of a variety of viral infections. It acts by modifying or stimulating cell-mediated immune processes rather than acting directly on the virus.
In vitro exposure of cells to inosiplex induces T-lymphocyte differentiation and potentiation of induced lymphoproliferative responses. The drug modulates T-lymphocyte and natural killer cell cytotoxicity, suppressor and helper cell functions. It also increases the number of IgG and complement surface markers. Interleukin-1 and -2 production, and neutrophil, monocyte and macrophage chemotaxis and phagocytosis are also potentiated by inosiplex.
In vivo antiviral and possible antitumor activity of inosiplex is believed to result from enhancement of host immune responses. The drug does not by itself stimulate resting lymphocytes but augments immunological processes by lymphocytes once they have been triggered by mitogens or viral agents.
Pharmacokinetics
Inosiplex is rapidly absorbed after oral doses and metabolized with a plasma t1/2 of 50 mins. The inosine portion of the complex yields uric acid and the other components undergo oxidation and glucuronidation. The metabolites are excreted in the urine.