Brand Name, Dosage Format and Strength
50 mg Tablet
Aminoglycoside, Cephalosporin, Chloramphenicol, Lincosamide, Macrolide, Penicillin, Penicillin + Beta lactamase Inhibitor , Penicillinase-resistant isoxazolylpenicillin, Penicillin; Beta-lactam + Beta-lactamase Inhibitor, Quinolone, Sulfonamide + Folate Inhibitor, Tetracycline, Triazole Antibiotic, Immunostimulant, Neuraminidase Inhibitor
Fluconazole is generally well tolerated. Most common adverse effects are abdominal pain, diarrhea, flatulence, nausea, vomiting, and taste disturbance. Other reported adverse effects include headache, dizziness, leukopenia, thrombocytopenia, hyperlipidemia, and raised liver enzyme concentrations.
Since fluconazole is used in patients with serious underlying diseases, there are some instances where causal relationship of the adverse event to the treatment is hard to establish.
GI: GI effects are the most common adverse reactions reported with fluconazole use. These reactions are usually mild to moderate in nature and do not usually require discontinuation of therapy. These adverse effects are nausea, vomiting, abdominal pain, and diarrhea. Rarely, there have been reports of flatus, bloating, dry mouth, hiccups, heartburn, and anorexia.
In patients with vulvovaginal candidiasis receiving single dose of fluconazole, abdominal pain, nausea, diarrhea, dyspepsia, and dysgeusia have been reported.
Dermatologic / Hypersensitivity Reactions: Rare reports of anaphylaxis have occurred. Rash (including diffuse rash with eosinophilia) and pruritus were also reported. SJS has also occurred and may be a fatal. In patients with serious diseases such as autoimmune deficiency syndrome (AIDS) or malignancy, exfoliative skin disorders have occurred. In patients with vulvovaginal candidiasis receiving single dose fluconazole, angioedema and anaphylaxis were reported rarely.
Hepatic: Rare but serious hepatotoxicity (e.g., necrosis, clinical hepatitis, cholestasis, fulminant hepatic failure) have been reported. Although these events may be reversible, there have been reports of death, especially involving patients with serious underlying conditions.
CNS: Dizziness and headache have occurred. Somnolence, delirium/coma, dysesthesia, psychiatric disturbances, malaise, paresthesia of hands and feet, fatigue, and seizure have been reported rarely.
Hematologic: Eosinophilia, anemia, leukopenia, neutropenia, and thrombocytopenia have been reported. Although thrombocytopenia may be reversible after drug discontinuation, there were reports of severe cases necessitating treatment.
Endocrine: Endocrine effects of fluconazole have not been studied. However, there have been reports of alterations on testosterone and endogenous corticosteroid concentrations, as well as changes in ACTH-stimulated cortisol response.
Other Adverse Effects: There have been rare reports of fever, edema, pleural effusion, oliguria, hypotension, arthralgia/myalgia, and finger stiffness. Alopecia was also reported, occurring in both genders after 3 mos of therapy. Alopecia may respond to either drug discontinuation or dose reduction. Fluconazole may also cause hair loss on the face, axillary, pubic, leg and chest area.