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Funzela
Fluconazole
Brand Name, Dosage Format and Strength
Funzela 50 mg Tablet
Therapeutic Category
Anti-infectives (Systemic)
Class
Aminoglycoside, Cephalosporin, Chloramphenicol, Lincosamide, Macrolide, Penicillin, Penicillin + Beta lactamase Inhibitor , Penicillinase-resistant isoxazolylpenicillin, Penicillin; Beta-lactam + Beta-lactamase Inhibitor, Quinolone, Sulfonamide + Folate Inhibitor, Tetracycline, Triazole Antibiotic, Immunostimulant, Neuraminidase Inhibitor
INTERACTION/S WITH OTHER MEDICAMENTS
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* Fluconazole Drug Interactions
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Precipitant Drug
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Object Drug
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Description
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Cimetidine
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Fluconazole
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¯
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Cimetidine resulted in a reduction in fluconazole AUC and Cmax.
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Hydrochloro-thiazide
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Fluconazole
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á
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Concomitant use resulted in a significant increase in fluconazole Cmax and AUC, which can be attributed to reduced renal clearance.
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Rifampicin
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Fluconazole
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¯
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A single oral fluconazole dose after chronic rifampicin resulted in a decrease in AUC and a shorter t1/2 of fluconazole.
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Aztemizole
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Fluconazole
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á
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Concomitant administration with fluconazole causes elevations in serum levels of these drugs. Caution should be exercised.
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Fluconazole
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Rifabutin
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á
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Concomitant use resulted in a significant increase in rifabutin serum levels
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Fluconazole
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Contraceptives, oral (OC)
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«
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Concurrent use with an OC containing ethinyl estradiol/levonorgestrel produced an overall mean increase in the levels of the OC components; however, in some cases there were decreases up to 47% and 33% of ethinyl estradiol and levonorgestrel levels, respectively.
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Fluconazole
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Ciclosporin
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á
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Significant increases in ciclosporin Cmax, Cmin, and AUC values occurred following fluconazole use.
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Fluconazole
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Phenytoin
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á
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Coadministration resulted in an increase of phenytoin AUC values.
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Fluconazole
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Theophylline
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á
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Theophylline AUC, Cmax, and t1/2 were significantly increased and clearance was decreased.
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Fluconazole
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Sulfonylureas
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á
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Fluconazole resulted in significant increases in Cmax and AUC of tolbutamide, glibenclamide, and glipizide. Several subjects experienced symptoms consistent with hypoglycemia; some required oral glucose treatment.
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Fluconazole
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Warfarin
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á
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A single warfarin dose after 14 days of fluconazole resulted in an increase in the PT response (area under the prothrombin time-time curve). Of 13 subjects, 1 experienced a twofold increase in PT response.
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Fluconazole
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Zidovudine
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á
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Significant increase in zidovudine AUC after fluconazole administration.
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Fluconazole
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Cisapride
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á
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Fluconazole significantly increased the AUC and Cmax of cisapride after both single and multiple dosing. Fluconazole also significantly increased the QTc interval in subjects receiving cisapride 20 mg four times a day for 5 days
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Fluconazole
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Tacrolimus
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á
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Concomitant use resulted in a significant increase in tacrolimus serum levels
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* á - Object drug increased ¯ - Object drug decreased « - Undetermined effect
Drug/Laboratory Interactions
Mild, transient increases in serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, g-glutamyltransferase, and bilirubin have been reported. The patient’s liver function should be closely monitored for signs of severe hepatotoxicity.