IMPORTANT NOTE. We strongly recommend that you consult your doctor for proper advice before using any medications, including vitamins, supplements, herbals and products for the skin.
Salbutamol (as sulfate) + Guaifenesin
Brand Name, Dosage Format and Strength
Asmalin Broncho 1 mg/ 50 mg per 5 mL Syrup
Corticosteroid, Anticholinergic, Beta2-Agonist, Leukotriene Inhibitor, Beta2-Agonist, Beta2-Agonist, Expectorant, Antiasthma-Beta2- Agonist, Mucolytic, Beta2-Agonist, Mucolytic, Antitussive, Nasal Decongestant, Analgesic-Antipyretic, Antitussive, Nasal Decongestant, Analgesic-Antipyretic, Nasal Decongestant, Antihistamine, Nasal Decongestant, Antihistamine, Analgesic-Antipyretic, Nasal Decongestant, Analgesic-Antipyretic, Alpha Adrenergic Agonist, Nasal Decongestant, Antihistamine, Analgesic-Antipyretic
Salbutamol is a selective short-acting beta2-adrenergic agonist with preferential effect on beta2-adrenergic receptors found in the respiratory tract. It stimulates adenyl cyclase, the enzyme which catalyzes the conversion of ATP to cAMP. cAMP mediates cellular responses such as bronchial smooth muscle relaxation resulting in bronchodilation.
Guaifenesin loosens and thins phlegm and bronchial secretions to ease expectoration.
Salbutamol is readily absorbed from the gastrointestinal tract after oral administration. Salbutamol’s onset of action is within 30 min, peaks in 2 to 3 hrs and persists for 6 hrs after a dose; the plasma half-life is from 4 to 6 hrs. It is extensively metabolized in the liver, being converted to salbutamol 4’-O-sulfate. Salbutamol and its metabolites are rapidly excreted in urine and feces. After oral administration of salbutamol to healthy individuals, about 75% of a single dose is excreted in urine within 72 hrs, mainly as the major metabolite; about 4% of the dose is excreted in feces.
Animal studies show that salbutamol can cross the blood-brain barrier and the placenta. It may be secreted in breast milk but concentrations are not known.
Guaifenesin is rapidly and well absorbed from the gastrointestinal tract. The t½ is approximately 1 hr. Guaifenesin is rapidly metabolized and then excreted in urine.