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Amoclav

Amoxicillin + Clavulanic acid




Brand Name, Dosage Format and Strength
Amoclav  400 mg/57 mg per 5 mL  Powder for Suspension

Therapeutic Category
Anti-infectives (Systemic)

Class
Aminoglycoside, Cephalosporin, Chloramphenicol, Lincosamide, Macrolide, Penicillin, Penicillin + Beta lactamase Inhibitor , Penicillinase-resistant isoxazolylpenicillin, Penicillin; Beta-lactam + Beta-lactamase Inhibitor, Quinolone, Sulfonamide + Folate Inhibitor, Tetracycline, Triazole Antibiotic, Immunostimulant, Neuraminidase Inhibitor


UNDESIRABLE EFFECTS

Dermatologic and Hypersensitivity Reactions: Angioneurotic edema, anaphylaxis, serum sickness-like syndrome, fever, hypersensitivity vasculitis, skin rash, pruritus, urticaria, angioedema, erythema multiforme (rarely SJS), toxic epidermal necrolysis, bullous exfoliative dermatitis, acute generalized exanthematous pustulosis (AGEP).  

GI: Abdominal discomfort, anorexia, and flatulence, dyspepsia, diarrhea/loose stools, nausea, vomiting, indigestion, CDAD and colitis (antibiotic-associated pseudomembranous colitis), gastritis, stomatitis, glossitis, black “hairy” tongue, mucocutaneous candidiasis, enterocolitis
 
Hematologic: Reversible leukopenia (including neutropenia) and thrombocytopenia, thrombocytopenic purpura, reversible agranulocytosis, anemia (including hemolytic anemia), slight thrombocytosis, eosinophilia, abnormal platelet aggregation, prolonged bleeding time and prothrombin time
 
CNS: Dizziness, headache, reversible hyperactivity and convulsions particularly in patients with impaired renal functions or those receiving high doses, agitation, anxiety, behavioral changes, confusion, insomnia
 
Hepatic: A moderate rise in AST and/or ALT, serum bilirubin and/or alkaline phosphatase, hepatitis, cholestatic jaundice, acute hepatic dysfunction
 
Renal/Genitourinary: Acute interstitial nephritis, crystalluria, vaginal itching, soreness and discharge
 
Other Effects: Superficial tooth discoloration (brown, yellow, or gray staining)

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