If you are reading this please do not access this site...use http://www.unilab.com.ph instead

Products

Find by Brand Name:
A  B  C  D  E  F  G  H  I  J  K  L  M 
N  O  P  Q  R  S  T  U  V  W  X  Y  Z 
Amoclav

Amoxicillin + Clavulanic acid




Brand Name, Dosage Format and Strength
Amoclav  400 mg/57 mg per 5 mL  Powder for Suspension


DOSAGE AND ADMINISTRATION

  • Administer Co-amoxiclav at the start of a meal to minimize potential Gl intolerance and to optimize absorption.
  • Drink plenty of water to ensure proper state of hydration and adequate urinary output.
  • Treatment should not exceed 14 days without first re-evaluating the patient.

Usual Oral Dosage in Adults and Children over 12 yrs old

Infections

Recommended Oral Co-amoxiclav Dose

Mild to moderate

375 mg tab every 8 hrs, OR

625 mg tab every 12 hrs

Dental (e.g., dentoalveolar abscess)

375 mg tab every 8 hrs for five days

Severe (including chronic and recurrent urinary tract infections and lower respiratory tract infections)

       625 mg tab every 8 hrs, OR

1 g tab every 12 hrs

Or, as prescribed by a physician.

 Dosage in Adult Patients and Children over 12 yrs old with Renal Impairment

CLCR (mL/min)

Recommended Oral Co-amoxiclav Dose

> 30

No dosage adjustment necessary

10 to 30

375 mg OR 625 mg tab every 12 hrs, depending on the severity of infection

 

<10

375 mg tab every 12 hrs, depending on the severity of infection.

625 mg tab is not recommended

Co-amoxiclav 1 g tab should only be used in patients with CLCR of >30 mL/min

Dosage in Adult Patients and Children over 12 yrs old on Hemodialysis: Co-amoxiclav 375 mg OR 625 mg tab every 24 hrs, depending on the severity of infection. Patients should receive an additional dose both during and at the end of dialysis.

Dosage in Adult Patients and Children over 12 yrs old with Hepatic Impairment: Dose with caution and monitor hepatic function regularly.

Usual Oral Dosage in Children up to 12 yrs old: Co-amoxiclav is dosed based on the amoxicillin component and is given in divided doses every 12 hrs.

  • Children below 1 yr old:                    30 mg/kg BW/day
  • For Mild to Moderate Infections:        25 mg/kg BW/day
  • For Severe Infections:                       45 mg/kg BW/day  

Age

Weight

 

Mild to Moderate Infections

Severe Infections

Co-amoxiclav 228.5 mg/5 mL

Co-amoxiclav 457 mg/5 mL

Co-amoxiclav 228.5 mg/5 mL

Co-amoxiclav 457 mg/5 mL

< 1 yr

< 10 kg

2.5 mL (1/2 tsp)

-

2.5 mL (1/2 tsp)

-

1 to 6 yrs

10 to 18 kg

2.5 to 5 mL

(1/2 to 1 tsp)

2.5 mL

(1/2 tsp)

5 to 10 mL

(1 to 2 tsp)

2.5 to 5 mL

(1/2 to1 tsp)

6 to 12 yrs

18 to 40 kg

5 to 10 mL

 (1 to 2 tsp)

2.5 to 5 mL

(1/2 to 1 tsp)

10 to 20 mL

(2 to 4 tsp)

5 to 10 mL

 (1 to 2 tsp)

  • Dose in children weighing over 40 kg and children over 12 yrs old is based on adult dosing recommendations. 
  • Or, as prescribed by a physician. 

 Dosage in Children up to 12 yrs old with Renal Impairment 

CLCR (mL/min)

Recommended Oral Dose

>30

No dosage adjustment necessary

10 to 30

15 mg/kg BW every 12 hrs

<10

15 mg/kg BW OD

In the majority of cases, treatment with parenteral Co-amoxiclav, where available, may be preferred.

Dosage in Children up to 12 yrs old on Hemodialysis: 15 mg/kg BW OD. Patients should receive an additional dose of 15 mg/kg BW both during and at the end of dialysis.

Dosage in Children up to 12 yrs old with Hepatic Impairment: Dose with caution and monitor hepatic function regularly. 

Directions for Reconstitution

Co-amoxiclav Powder for Suspension

Volume of Distilled Water to be added

 Directions

 

228.5 mg/5 mL

 

58 mL

 

To make up to 70 mL, first tap the bottle several times to loosen the powder before reconstitution. Then add the required amount of distilled water in two portions and shake vigorously until all contents are evenly suspended.

 

457 mg/5 mL

 

59 mL

Shake well before taking each dose. Once reconstituted, the suspension must be stored in a refrigerator (2°C to 8°C). Discard any unused portion after 7 days.

Last Update: Jul 20, 2011


Already Registered?

Remember Me

I forgot my username & password